Gene

Pcbd1

Species
Rattus norvegicus
Symbol
Pcbd1
Name
pterin-4 alpha-carbinolamine dehydratase 1
Synonyms
  • 4-alpha-hydroxy-tetrahydropterin dehydratase
  • 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
Biotype
protein coding gene
Automated Description
Enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity and transcription coactivator activity. Involved in L-phenylalanine metabolic process. Acts upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia D. Orthologous to human PCBD1 (pterin-4 alpha-carbinolamine dehydratase 1).
RGD Description
Enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity and transcription coactivator activity. Involved in L-phenylalanine metabolic process. Acts upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia D. Orthologous to human PCBD1 (pterin-4 alpha-carbinolamine dehydratase 1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 6-propyl-2-thiouracil.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12599
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
28.96M28.97M28.98M28.99M29.00M29.01M29.02M29.03M29.04M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions