Gene

Xiap

Species
Rattus norvegicus
Symbol
Xiap
Name
X-linked inhibitor of apoptosis
Synonyms
  • Api3
  • apoptosis inhibitor protein 3
Biotype
protein coding gene
Automated Description
Enables protease binding activity and scaffold protein binding activity. Involved in cellular response to hydrogen peroxide and negative regulation of neuron apoptotic process. Located in perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of apoptosis).
RGD Description
Enables protease binding activity and scaffold protein binding activity. Involved in cellular response to hydrogen peroxide and negative regulation of neuron apoptotic process. Located in perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of apoptosis); PARTICIPATES IN intrinsic apoptotic pathway; Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10044
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
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      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
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            120.895M120.900M120.905M120.910M120.915M120.920M120.925M120.930M120.935M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Xiap molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              Xiap role
              Xiap genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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