Gene

Hmga1

Species
Rattus norvegicus
Symbol
Hmga1
Name
high mobility group AT-hook 1
Synonyms
  • high mobility group AT-hook protein 1
  • high mobility group protein A1
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including DNA binding activity; catalytic activity, acting on DNA; and nuclear receptor coactivator activity. Predicted to be involved in several processes, including base-excision repair; oncogene-induced cell senescence; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including hemopoiesis; insulin receptor signaling pathway; and peroxisome proliferator activated receptor signaling pathway. Predicted to be located in male germ cell nucleus and senescence-associated heterochromatin focus. Predicted to be part of RNA polymerase II transcription regulator complex and SUMO ligase complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human HMGA1 (high mobility group AT-hook 1).
RGD Description
Predicted to enable several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and catalytic activity, acting on DNA. Predicted to be involved in several processes, including base-excision repair; oncogene-induced cell senescence; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including hemopoiesis; insulin receptor signaling pathway; and peroxisome proliferator activated receptor signaling pathway. Predicted to be located in male germ cell nucleus and senescence-associated heterochromatin focus. Predicted to be part of RNA polymerase II transcription regulator complex and SUMO ligase complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human HMGA1 (high mobility group AT-hook 1); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23341
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
5.612M5.613M5.614M5.615M5.616M5.617M5.618M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions