Predicted to enable several functions, including DNA binding activity; catalytic activity, acting on DNA; and nuclear receptor coactivator activity. Predicted to be involved in several processes, including base-excision repair; oncogene-induced cell senescence; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including hemopoiesis; insulin receptor signaling pathway; and peroxisome proliferator activated receptor signaling pathway. Predicted to be located in male germ cell nucleus and senescence-associated heterochromatin focus. Predicted to be part of RNA polymerase II transcription regulator complex and SUMO ligase complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human HMGA1 (high mobility group AT-hook 1).
RGD Description
Predicted to enable several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and catalytic activity, acting on DNA. Predicted to be involved in several processes, including base-excision repair; oncogene-induced cell senescence; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including hemopoiesis; insulin receptor signaling pathway; and peroxisome proliferator activated receptor signaling pathway. Predicted to be located in male germ cell nucleus and senescence-associated heterochromatin focus. Predicted to be part of RNA polymerase II transcription regulator complex and SUMO ligase complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human HMGA1 (high mobility group AT-hook 1); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose.