Gene

Ascl1

Species
Rattus norvegicus
Symbol
Ascl1
Name
achaete-scute family bHLH transcription factor 1
Synonyms
  • achaete-scute complex (Drosophila) homolog-like 1
  • achaete-scute complex homolog 1
Biotype
protein coding gene
Automated Description
Enables double-stranded DNA binding activity and identical protein binding activity. Involved in several processes, including cellular response to magnetism; regulation of neuron differentiation; and response to retinoic acid. Predicted to be located in neuronal cell body and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Biomarker of status epilepticus. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1).
RGD Description
Enables double-stranded DNA binding activity and identical protein binding activity. Involved in several processes, including cellular response to magnetism; regulation of neuron differentiation; and response to retinoic acid. Predicted to be located in neuronal cell body and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Biomarker of status epilepticus. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1); INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23349
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            21.9035M21.9040M21.9045M21.9050M21.9055M21.9060M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Ascl1 molecule type
            Interactor gene
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              Genetic Interactions

              Ascl1 role
              Ascl1 genetic perturbation
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