Version: 8.0.0
Date: Tue Jan 28 2025
FUN12
Saccharomyces cerevisiaeSGD:S000000033
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

FUN12

Species
Saccharomyces cerevisiae
Symbol
FUN12
Name
Function Unknown Now
Synonyms
  • eIF5B
  • YAL035W
Biotype
protein coding gene
Automated Description
Enables several functions, including GTP binding activity; GTPase activity; and nucleic acid binding activity. Involved in formation of cytoplasmic translation initiation complex; regulation of translational initiation; and ribosome biogenesis. Located in cytoplasmic stress granule; cytosol; and mitochondrion. Part of cytosolic small ribosomal subunit and eukaryotic 48S preinitiation complex. Orthologous to human EIF5B (eukaryotic translation initiation factor 5B).
SGD Description
Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43381:SF4
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R64-5-1
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            76.5k77.0k77.5k78.0k78.5k79.0k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            FUN12 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              FUN12 role
              FUN12 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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