Enables small GTPase binding activity. Involved in several processes, including fungal-type cell wall organization; intracellular protein transport; and response to pH. Acts upstream of or within protein lipidation. Located in cytosol. Is active in late endosome. Used to study Chediak-Higashi syndrome. Human ortholog(s) of this gene implicated in Chediak-Higashi syndrome and primary autosomal dominant microcephaly 18. Orthologous to several human genes including WDFY4 (WDFY family member 4).
SGD Description
Endosomal protein involved in endocytosis and autophagy; homologous to Chediak-Higashi syndrome and Beige proteins, both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting