Enables ATP hydrolysis activity; chromatin binding activity; and mRNA binding activity. Involved in several processes, including membraneless organelle assembly; post-transcriptional regulation of gene expression; and pseudohyphal growth. Located in P-body; cytoplasmic side of membrane; and cytoplasmic stress granule. Orthologous to human DDX6 (DEAD-box helicase 6).
SGD Description
Cytoplasmic DEAD-box helicase and mRNA decapping activator; interacts with decapping and deadenylase complexes to coordinate mRNA decapping and decay; regulates general translational repression; translational activator of select mRNAs during filamentous growth, mating and autophagy; cooperates with Ngr1p to promote specific mRNA decay; ATP- and RNA-bound form promotes processing body assembly, while ATPase stimulation by Not1p promotes disassembly; forms cytoplasmic foci on replication stress