Gene

DHH1

Species
Saccharomyces cerevisiae
Symbol
DHH1
Name
DEAD box Helicase Homolog
Synonyms
  • YDL160C
Biotype
protein coding gene
Automated Description
Enables ATP hydrolysis activity; chromatin binding activity; and mRNA binding activity. Involved in several processes, including membraneless organelle assembly; post-transcriptional regulation of gene expression; and pseudohyphal growth. Located in P-body; cytoplasmic side of membrane; and cytoplasmic stress granule. Orthologous to human DDX6 (DEAD-box helicase 6).
SGD Description
Cytoplasmic DEAD-box helicase and mRNA decapping activator; interacts with decapping and deadenylase complexes to coordinate mRNA decapping and decay; regulates general translational repression; translational activator of select mRNAs during filamentous growth, mating and autophagy; cooperates with Ngr1p to promote specific mRNA decay; ATP- and RNA-bound form promotes processing body assembly, while ATPase stimulation by Not1p promotes disassembly; forms cytoplasmic foci on replication stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47960:SF17
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions