Gene

LRG1

Species
Saccharomyces cerevisiae
Symbol
LRG1
Name
Lim-RhoGap homolog
Synonyms
  • YDL240W
Biotype
protein coding gene
Automated Description
Enables GTPase activator activity. Involved in several processes, including negative regulation of Rho protein signal transduction; regulation of cell wall (1->3)-beta-D-glucan biosynthetic process; and regulation of fungal-type cell wall organization. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP1 (cysteine and glycine rich protein 1); CSRP2 (cysteine and glycine rich protein 2); and CSRP3 (cysteine and glycine rich protein 3).
SGD Description
GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24215:SF10
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R64-5-1
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            23.0k23.5k24.0k24.5k25.0k25.5k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            LRG1 molecule type
            Interactor gene
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              Genetic Interactions

              LRG1 role
              LRG1 genetic perturbation
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