Gene

MLG1

Species
Saccharomyces cerevisiae
Symbol
MLG1
Name
hoMoLoG to PSI1
Synonyms
  • YDR018C
Biotype
protein coding gene
Automated Description
Enables lysophosphatidic acid acyltransferase activity. Involved in phosphatidic acid biosynthetic process. Acts upstream of or within phosphatidylethanolamine acyl-chain remodeling and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum and nucleus. Is active in mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to several human genes including AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3) and AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4).
SGD Description
Lysolipid acyltransferase; involved in the synthesis of phosphatidic acid from 1-acyl-2-hydroxy-sn-glycero-3-phosphate using oleoyl-CoA as acyl donor and in phospholipid remodeling, incorporating palmitic acid into the sn-1 position of phosphatidylserine and phosphatidylethanolamine; localizes to ER membranes associated with mitochondria (MAMs); contains three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10983:SF16
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R64-5-1
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            482.8k483.0k483.2k483.4k483.6k483.8k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            MLG1 molecule type
            Interactor gene
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              Genetic Interactions

              MLG1 role
              MLG1 genetic perturbation
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