Gene

CNA1

Species
Saccharomyces cerevisiae
Symbol
CNA1
Name
CalciNeurin A
Synonyms
  • CMP1
  • YLR433C
Biotype
protein coding gene
Automated Description
Contributes to calcium-dependent protein serine/threonine phosphatase activity. Involved in several processes, including cellular response to pheromone; conjugation with cellular fusion; and fungal-type cell wall organization. Part of calcineurin complex. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha); PPP3CB (protein phosphatase 3 catalytic subunit beta); and PPP3CC (protein phosphatase 3 catalytic subunit gamma).
SGD Description
Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog, CMP2, that arose from the whole genome duplication
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45673:SF1
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
1.0044M1.0046M1.0048M1.0050M1.0052M1.0054M1.0056M1.0058M1.0060M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions