Gene

GLO1

Species
Saccharomyces cerevisiae
Symbol
GLO1
Name
GLyOxalase
Synonyms
  • YML004C
Biotype
protein coding gene
Automated Description
Enables lactoylglutathione lyase activity. Involved in glutathione metabolic process and methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I).
SGD Description
Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; required for full activity of O-acetyl homoserine sulfhydrylase, Met17p; expression regulated by methylglyoxal levels and osmotic stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10374:SF30
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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261.8k261.9k262.0k262.1k262.2k262.3k262.4k262.5k262.6k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions