Enables structural molecule activity. Involved in DNA metabolic process; chromatin looping; and chromosome organization. Acts upstream of or within synaptonemal complex assembly. Located in condensed nuclear chromosome and cytosol. Part of meiotic recombination initiation complex. Orthologous to human PDS5A (PDS5 cohesin associated factor A) and PDS5B (PDS5 cohesin associated factor B).
SGD Description
Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by protecting the integrity of the cohesion complex; regulates homolog pairing and facilitates synaptonemal complex formation, axis formation, interhomolog recombination and synapsis during meiosis; relocalizes to the cytosol in response to hypoxia; scaffolding protein contains 26 HEAT repeats