Gene

PDS5

Species
Saccharomyces cerevisiae
Symbol
PDS5
Name
Precocious Dissociation of Sisters
Synonyms
  • YMR076C
Biotype
protein coding gene
Automated Description
Enables structural molecule activity. Involved in DNA metabolic process; chromatin looping; and chromosome organization. Acts upstream of or within synaptonemal complex assembly. Located in condensed nuclear chromosome and cytosol. Part of meiotic recombination initiation complex. Orthologous to human PDS5A (PDS5 cohesin associated factor A) and PDS5B (PDS5 cohesin associated factor B).
SGD Description
Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by protecting the integrity of the cohesion complex; regulates homolog pairing and facilitates synaptonemal complex formation, axis formation, interhomolog recombination and synapsis during meiosis; relocalizes to the cytosol in response to hypoxia; scaffolding protein contains 26 HEAT repeats
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12663:SF0
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions