Gene

ERG2

Species
Saccharomyces cerevisiae
Symbol
ERG2
Name
ERGosterol biosynthesis
Synonyms
  • END11
  • YMR202W
Biotype
protein coding gene
Automated Description
Enables C-8 sterol isomerase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum. Used to study amyotrophic lateral sclerosis type 16. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 16 and autosomal recessive distal hereditary motor neuronopathy 2. Orthologous to human SIGMAR1 (sigma non-opioid intracellular receptor 1).
SGD Description
C-8 sterol isomerase; catalyzes isomerization of delta-8 double bond to delta-7 position at an intermediate step in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutation is functionally complemented by human EBP
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10868:SF1
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
667.6k667.7k667.8k667.9k668.0k668.1k668.2k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions