Gene

IGO1

Species
Saccharomyces cerevisiae
Symbol
IGO1
Name
Initiation of G zerO
Synonyms
  • YNL157W
Biotype
protein coding gene
Automated Description
Enables protein serine/threonine phosphatase inhibitor activity. Involved in cellular response to heat; negative regulation of mRNA catabolic process; and positive regulation of cell cycle process. Located in P-body and nucleus.
SGD Description
Protein required for initiation of the G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylation (S63) by Rim15p increases interaction with and inhibition of PP2A-Cdc55 for timely mitotic progression; can also activate PP2A-Cdc55 complexes and influence Cdc55p localization along with Igo2p; GFP protein localizes to the cytoplasm and nucleus; IGO1 has a paralog, IGO2, that arose from the whole genome duplication
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10358:SF6
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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340.40k340.45k340.50k340.55k340.60k340.65k340.70k340.75k340.80k340.85k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions