Enables glutathione synthase activity. Involved in glutathione biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase).
SGD Description
Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock