Gene

coq-2

Species
Caenorhabditis elegans
Symbol
coq-2
Name
COenzyme Q (ubiquinone) biosynthesis 2
Synonyms
  • CELE_F57B9.4
  • F57B9.4
Biotype
protein coding gene
Automated Description
Predicted to enable 4-hydroxybenzoate polyprenyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Orthologous to human COQ2 (coenzyme Q2, polyprenyltransferase).
WB Description
coq-2 encodes a putative para-hydroxybenzoate-polyprenyl transferase(UbiA prenyltransferase), orthologous to S. cerevisiae COQ2; COQ-2 isrequired for ubiquinone (coenzyme Q9) biosynthesis and for normallyshort lifespan; coq-2 mutants have slowed pharyngeal pumping, andeventually arrest as paralysed larvae before dying; coq-2(RNAi) animalshave reduced levels of coenzyme Q9 and superoxide, and have abnormallylong lifespans; coq-2 mutants are not rescued by dietary coenzyme Q.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11048
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
6.9360M6.9365M6.9370M6.9375M6.9380M6.9385M6.9390M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions