Predicted to enable 4-hydroxybenzoate polyprenyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Orthologous to human COQ2 (coenzyme Q2, polyprenyltransferase).
WB Description
coq-2 encodes a putative para-hydroxybenzoate-polyprenyl transferase(UbiA prenyltransferase), orthologous to S. cerevisiae COQ2; COQ-2 isrequired for ubiquinone (coenzyme Q9) biosynthesis and for normallyshort lifespan; coq-2 mutants have slowed pharyngeal pumping, andeventually arrest as paralysed larvae before dying; coq-2(RNAi) animalshave reduced levels of coenzyme Q9 and superoxide, and have abnormallylong lifespans; coq-2 mutants are not rescued by dietary coenzyme Q.