Gene

ddp-1

Species
Caenorhabditis elegans
Symbol
ddp-1
Name
human DDP related 1
Synonyms
  • CELE_Y39A3CR.4
  • tim-8
Biotype
protein coding gene
Automated Description
Predicted to enable metal ion binding activity. Involved in mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Used to study deafness-dystonia-optic neuronopathy syndrome. Human ortholog(s) of this gene implicated in deafness-dystonia-optic neuronopathy syndrome and dystonia. Orthologous to several human genes including TIMM8A (translocase of inner mitochondrial membrane 8A).
WB Description
ddp-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Tim8p and human TIMM8A or deafness/dystonia peptide; DDP-1 is predicted to be part of a heterooligomeric complex that localizes to the mitochondrial intermembrane space and facilitates translocation of proteins from the cytosol to the inner mitochondrial membrane; in C. elegans, DDP-1 is required for normal mitochondrial morphology.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19338
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            1.85990M1.85995M1.86000M1.86005M1.86010M1.86015M1.86020M1.86025M1.86030M1.86035M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ddp-1 molecule type
            Interactor gene
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              Genetic Interactions

              ddp-1 role
              ddp-1 genetic perturbation
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