Gene

emb-8

Species
Caenorhabditis elegans
Symbol
emb-8
Name
abnormal EMBroygenesis 8
Synonyms
  • CELE_K10D2.6
  • drop-8
Biotype
protein coding gene
Automated Description
Predicted to enable FMN binding activity; NADPH-hemoprotein reductase activity; and flavin adenine dinucleotide binding activity. Involved in eggshell formation and lipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Is expressed in intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in Antley-Bixler syndrome with disordered steroidogenesis; congenital adrenal hyperplasia; and cytochrome P450 oxidoreductase deficiency. Orthologous to human POR (cytochrome p450 oxidoreductase).
WB Description
emb-8 encodes the C. elegans NADPH-cytochrome P450 reductase ortholog; by homology, EMB-8 is predicted to function in the enzymatic reduction of the cytochrome P450 monooxygenase enzymes that play a role in fatty acid modification; during embryonic development, emb-8 activity is essential for normal interactions between the pronucleus/centrosome complex and the posterior cortex and thus, for proper anterior-posterior (A/P) polarity and localization of GLP-1, PAR-3, PAR-2, and P granules; emb-8 is also required for formation of the secreted eggshell; genetic studies indicate that, in regulating A/P polarity, emb-8 appears to function in the same pathway as pod-1 and pod-2.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19384
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            5.1970M5.1975M5.1980M5.1985M5.1990M5.1995M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            emb-8 molecule type
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              Genetic Interactions

              emb-8 role
              emb-8 genetic perturbation
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