Gene

glr-3

Species
Caenorhabditis elegans
Symbol
glr-3
Name
GLutamate Receptor family (AMPA) 3
Synonyms
  • CELE_K10D3.1
  • K10D3.1
Biotype
protein coding gene
Automated Description
Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in detection of cold stimulus involved in thermoception and detection of temperature stimulus involved in sensory perception of pain. Predicted to be located in postsynaptic membrane. Predicted to be active in postsynaptic density membrane. Is expressed in RIAL and RIAR. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to several human genes including GRIK3 (glutamate ionotropic receptor kainate type subunit 3) and GRIK4 (glutamate ionotropic receptor kainate type subunit 4).
WB Description
glr-3 encodes a protein that contains a ligand-gated ion channel domain and a receptor family ligand binding domain with similarity to kainate-selective ionotropic glutamate receptor 2 (human GRIK2); expressed in the RIA neuron.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18966
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            7.1180M7.1185M7.1190M7.1195M7.1200M7.1205M7.1210M7.1215M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            glr-3 molecule type
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              Genetic Interactions

              glr-3 role
              glr-3 genetic perturbation
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