Gene

gpb-2

Species
Caenorhabditis elegans
Symbol
gpb-2
Name
G Protein, Beta subunit 2
Synonyms
  • CELE_F52A8.2
  • eat-11
Biotype
protein coding gene
Automated Description
Predicted to enable signaling receptor complex adaptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of egg-laying behavior; and regulation of nematode pharyngeal pumping. Located in neuronal cell body. Is expressed in body wall musculature; neurons; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in intellectual developmental disorder with cardiac arrhythmia. Orthologous to human GNB5 (G protein subunit beta 5).
WB Description
gpb-2 encodes an ortholog of Gbeta(5), that is dispensable for viability, but required for normal egg-laying, locomotion, and pharyngeal pumping; GBP-2 may regulate the interaction between the GOA-1 and EGL-30 signaling pathways based on genetic analysis; gpb-2 is expressed throughout development in the nervous system and in muscle, and expression is dependent upon expression of both EAT-16 and EGL-10.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19850
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
gpb-1133969497 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
amplitude of sinusoidal movement variant
arecoline hypersensitive
backward locomotion variant
backward point velocity variant
body posture amplitude increased
body posture wavelength increased
coiler
fat
forward point velocity decreased
frequency of body bend variant
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
DA541WB
DA810WB
JT603WB
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Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
7.3185M7.3190M7.3195M7.3200M7.3205M7.3210M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

17 interactor genes based on 23 annotations
gpb-2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
eat-16Caenorhabditis elegans
protein
  • two hybrid
PMID:11333232
protein
egl-10Caenorhabditis elegans
protein
  • two hybrid
PMID:11333232
protein
egl-10Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:12354761
protein
gpc-1Caenorhabditis elegans
protein
  • two hybrid
PMID:11333232
protein
gpc-2Caenorhabditis elegans
protein
  • two hybrid
PMID:11333232
protein
lin-53Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:31397537
protein
rsbp-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:19923320
protein
smo-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:29348603
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Genetic Interactions