Gene

grh-1

Species
Caenorhabditis elegans
Symbol
grh-1
Name
GRainyHead (Drosophila transcription factor) homolog 1
Synonyms
  • CELE_Y48G8AR.1
  • Y48G8AR.1
Biotype
protein coding gene
Automated Description
Enables sequence-specific double-stranded DNA binding activity. Involved in defense response to bacterium; determination of adult lifespan; and ecdysis, collagen and cuticulin-based cuticle. Located in chromatin and nucleus. Is expressed in head neurons; hypodermis; pharyngeal cell; and vulval precursor cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL1 (grainyhead like transcription factor 1); GRHL2 (grainyhead like transcription factor 2); and GRHL3 (grainyhead like transcription factor 3).
WB Description
grh-1 encodes a LSF/GRH transcription factor homolog required for normal cuticular synthesis and embryonic development; both GRH-1 and its Drosophila homolog GRAINYHEAD bind to DNA sites upstream of dbl-1, mab-5, and tdc-1; all three of these target genes are homologs of genes regulated by GRAINYHEAD in Drosophila; grh-1(RNAi) animals die as embryos with soft, defective cuticles, which resembles the phenotype seen in Drosophila grainyhead mutants.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11037
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
1.259M1.260M1.261M1.262M1.263M1.264M1.265M1.266M1.267M1.268M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions