Gene

kin-16

Species
Caenorhabditis elegans
Symbol
kin-16
Name
protein KINase 16
Synonyms
  • CELE_M176.7
  • M176.7
Biotype
protein coding gene
Automated Description
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in hyp6 and hyp7 syncytium.
WB Description
kin-16 encodes a novel receptor protein tyrosine kinase; like kin-15, with which it is cotranscribed, kin-16 encodes a protein that displays some unusual features, including a very small extracellular domain (50 amino acids) that lacks a cysteine-rich region typical of ligand-binding domains of known receptor tyrosine kinases, an unusual amino acid substitution in the subdomain VI motif, and a lack of typical autophosphorylation sites in the kinase insert and C-terminal domains; a kin-16 reporter is first detected in young L1 larvae in the hyp7 syncytium; later expression is detected in ventral and lateral cells that fuse with hyp7 as well as in the more anterior hyp6 syncytium late in development; this distinct expression pattern suggests that kin-16 may also play a role in development of the hypodermal syncytium and perhaps be involved in cell-cell interactions regulating postembryonic cell fusions.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24416
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            9.4342M9.4344M9.4346M9.4348M9.4350M9.4352M9.4354M9.4356M9.4358M9.4360M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            kin-16 molecule type
            Interactor gene
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              Genetic Interactions

              kin-16 role
              kin-16 genetic perturbation
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