Gene

blmp-1

Species
Caenorhabditis elegans
Symbol
blmp-1
Name
Blimp1 (B Lymphocyte-induced Maturation Protein-1) homolog 1
Synonyms
  • CELE_F25D7.3
  • dpy-24
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of distal tip cell migration; positive regulation of nematode male tail tip morphogenesis; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including distal tip cell; dorsal nerve cord; enteric muscle; hypodermis; and neurons. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human PRDM1 (PR/SET domain 1).
WB Description
blmp-1 encodes a zinc finger and SET domain-containing protein that is the C. elegans BLIMP1 (B lymphocyte-induced maturation protein 1) ortholog; loss of blmp-1 activity via deletion mutation has been reported to result in small, dumpy animals with abnormal fat content, while loss of blmp-1 activity via RNAi reportedly results in animals that are small, dumpy, have an amorphous pharynx, and are uncoordinated with patchy coloration and protruding vulvae; a blmp-1::gfp transcriptional fusion is expressed from late embryogenesis through adulthood and found in a variety of tissues including hypodermis, seam cells, gonad distal tip cells and vulva, ventral nerve cord, amphids and phasmids, and rectal muscles.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16515
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
10.4095M10.4100M10.4105M10.4110M10.4115M10.4120M10.4125M10.4130M10.4135M10.4140M10.4145M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions