Gene

pgp-13

Species
Caenorhabditis elegans
Symbol
pgp-13
Name
P-GlycoProtein related 13
Synonyms
  • CELE_F22E10.2
  • F22E10.2
Biotype
protein coding gene
Automated Description
Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in amphid neurons and intestine.
WB Description
pgp-13 encodes a member of the ABC transporter family with high similarity to the vertebrate MDR (multidrug resistance) family; PGP-13 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-13 activity via large-scale RNAi screens does not result in any obvious defects, the precise role of pgp-13 in C. elegans development and/or behavior is not yet known; pgp-13 promoter-gfp fusion proteins are expressed in larvae and adults in the posterior intestine and the amphids.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24221
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            12.7390M12.7395M12.7400M12.7405M12.7410M12.7415M12.7420M12.7425M12.7430M12.7435M12.7440M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            pgp-13 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              pgp-13 role
              pgp-13 genetic perturbation
              Interactor gene
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