Gene

spk-1

Species
Caenorhabditis elegans
Symbol
spk-1
Name
SR Protein Kinase 1
Synonyms
  • B0464.5
  • CELE_B0464.5
Biotype
protein coding gene
Automated Description
Enables protein serine/threonine kinase activity. Involved in embryo development and protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including hypodermis; intestine; nervous system; pharyngeal-intestinal valve; and reproductive system. Orthologous to human SRPK1 (SRSF protein kinase 1); SRPK2 (SRSF protein kinase 2); and SRPK3 (SRSF protein kinase 3).
WB Description
spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24055
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.457M9.458M9.459M9.460M9.461M9.462M9.463M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions