Gene

srp-1

Species
Caenorhabditis elegans
Symbol
srp-1
Name
SeRPin 1
Synonyms
  • C05E4.3
  • CELE_C05E4.3
Biotype
protein coding gene
Automated Description
Predicted to enable peptidase activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in proteolysis. Located in endoplasmic reticulum. Is expressed in arcade cell and body wall musculature. Human ortholog(s) of this gene implicated in several diseases, including familial encephalopathy with neuroserpin inclusion bodies; intermediate coronary syndrome; peeling skin syndrome 5; thrombophilia (multiple); and toxic shock syndrome. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB11 (serpin family B member 11); and SERPINB3 (serpin family B member 3).
WB Description
srp-1 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily; by homology, SRP-1 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11461
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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753.4k753.6k753.8k754.0k754.2k754.4k754.6k754.8k755.0k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions