Predicted to enable peptidase activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in proteolysis. Located in endoplasmic reticulum. Is expressed in arcade cell and body wall musculature. Human ortholog(s) of this gene implicated in several diseases, including familial encephalopathy with neuroserpin inclusion bodies; intermediate coronary syndrome; peeling skin syndrome 5; thrombophilia (multiple); and toxic shock syndrome. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB11 (serpin family B member 11); and SERPINB3 (serpin family B member 3).
WB Description
srp-1 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily; by homology, SRP-1 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases.