Gene

srp-7

Species
Caenorhabditis elegans
Symbol
srp-7
Name
SeRPin 7
Synonyms
  • CELE_F20D6.4
  • F20D6.4
Biotype
protein coding gene
Automated Description
Predicted to enable peptidase activity and serine-type endopeptidase inhibitor activity. Involved in IRE1-mediated unfolded protein response. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; Nagashima-type palmoplantar keratosis; autosomal recessive nonsyndromic deafness 91; familial encephalopathy with neuroserpin inclusion bodies; and thrombophilia (multiple). Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB11 (serpin family B member 11); and SERPINB3 (serpin family B member 3).
WB Description
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autosomal recessive nonsyndromic deafness 91; and thrombophilia (multiple). Is an ortholog of several human genes including SERPINB1 (serpin family B member 1); SERPINB8 (serpin family B member 8); and SERPINC1 (serpin family C member 1).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11461
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            8.1795M8.1800M8.1805M8.1810M8.1815M8.1820M8.1825M8.1830M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            srp-7 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              srp-7 role
              srp-7 genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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