Gene

lim-9

Species
Caenorhabditis elegans
Symbol
lim-9
Name
LIM domain family 9
Synonyms
  • CELE_F25H5.1
  • F25H5.1
Biotype
protein coding gene
Automated Description
Enables protein domain specific binding activity. Located in M band. Is expressed in several structures, including body wall musculature; excretory canal; non-striated muscle; spermatheca; and vulva. Orthologous to several human genes including FHL2 (four and a half LIM domains 2).
WB Description
lim-9 encodes a protein containing one PET domain and six LIM domains and is orthologous to Drosophila LIMPET and vertebrate FHL2; in vitro binding and yeast two-hybrid assays indicate that LIM-9 physically interacts with UNC-96 and UNC-97 and thus, is likely a component of a protein complex that links muscle focal adhesions to thick filaments; LIM-9 also enables Wnt-directed planar cell polarity and is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak; a lim-9::gfp promoter fusion is expressed in pharyngeal and body wall muscles, as well as in some neuronal processes, vulva, spermathecae, anal sphincter and depressor muscles, gonadal sheath, and the excretory canal; staining with LIM-9 antibodies reveals that in body wall muscle LIM-9 localizes, at least partially, to M-lines, around which myosin thick filaments are organized.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24205
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.185M9.190M9.195M9.200M9.205M9.210M9.215M9.220M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions