Enables protein domain specific binding activity. Located in M band. Is expressed in several structures, including body wall musculature; excretory canal; non-striated muscle; spermatheca; and vulva. Orthologous to several human genes including FHL2 (four and a half LIM domains 2).
WB Description
lim-9 encodes a protein containing one PET domain and six LIM domains and is orthologous to Drosophila LIMPET and vertebrate FHL2; in vitro binding and yeast two-hybrid assays indicate that LIM-9 physically interacts with UNC-96 and UNC-97 and thus, is likely a component of a protein complex that links muscle focal adhesions to thick filaments; LIM-9 also enables Wnt-directed planar cell polarity and is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak; a lim-9::gfp promoter fusion is expressed in pharyngeal and body wall muscles, as well as in some neuronal processes, vulva, spermathecae, anal sphincter and depressor muscles, gonadal sheath, and the excretory canal; staining with LIM-9 antibodies reveals that in body wall muscle LIM-9 localizes, at least partially, to M-lines, around which myosin thick filaments are organized.