Gene

vha-4

Species
Caenorhabditis elegans
Symbol
vha-4
Name
Vacuolar H ATPase 4
Synonyms
  • CELE_T01H3.1
  • T01H3.1
Biotype
protein coding gene
Automated Description
Predicted to enable proton transmembrane transporter activity. Involved in embryo development. Predicted to be part of proton-transporting two-sector ATPase complex, proton-transporting domain. Predicted to be active in membrane. Is expressed in excretory cell and rectum. Orthologous to human ATP6V0B (ATPase H+ transporting V0 subunit b).
WB Description
vha-4 encodes an ortholog of subunit c'' of the membrane-bound (V0)domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-4 is apredicted V-ATPase transmembrane rotor component; VHA-4 is paralogous tothe c subunits VHA-1/-2/-3, and is predicted to help carry protons fromthe cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) fortransmembrane export; VHA-4 is required for ovulation and embryogenesis,since vha-4(RNAi) animals are sterile with polyploid, unmatured oocytesand dead progeny; VHA-4 is required for alae formation, like the V0subunits VHA-1 and VHA-5, but not like the V1 subunits VHA-8 or VHA-13;vha-4 is expressed in the excretory cell, the rectum, and a pair ofcells near the anus.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10263
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            7.8782M7.8784M7.8786M7.8788M7.8790M7.8792M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            vha-4 molecule type
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              Genetic Interactions

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