Gene

wah-1

Species
Caenorhabditis elegans
Symbol
wah-1
Name
Worm AIF (apoptosis inducing factor) Homolog 1
Synonyms
  • CELE_Y56A3A.32
  • Y56A3A.32
Biotype
protein coding gene
Automated Description
Enables enzyme binding activity. Involved in apoptotic DNA fragmentation and positive regulation of phosphatidylserine exposure on apoptotic cell surface. Located in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1).
WB Description
wah-1 encodes a putative flavin-adenine dinucleotide (FAD)-bindingoxidoreductase orthologous to mammalian PDCD8 (AIF; OMIM:300169, mutatedin Harlequin mice); WAH-1 is required for apoptotic DNA degratation,SCRM-1 phospholipid scramblase activity, phosphatidylserine exposure,rapid apoptosis during embryonic development, and rapid engulfment ofapoptotic cells in the germline; WAH-1 is also required for normallyrapid growth and large brood sizes, and has a subtle proapoptoticfunction revealed in ced-3 or ced-4 mutant backgrounds; WAH-1 isexpressed in most, if not all, cells of embryos and larvae; WAH-1 isnormally mitochondrial, but can be released into the cytosol and nucleusby EGL-1 and CED-3; residues 380-550 of WAH-1 specifically bind SCRM-1in vitro, but not SCRM-2 through SCRM-4, and WAH-1 binding is requiredin liposomes for more than residual SCRM-1 activity; WAH-1 also bindsand activates CPS-6, promoting apoptotic DNA degradation, and transgeniccoexpression of WAH-1 with CPS-6 specifically induces ectopicCED-3-dependent apoptosis in touch receptor neurons; CPS-6 shares agenetic pathway with WAH-1, whereas CED-3, CED-4, CED-8, and NUC-1 actindependently of it; WAH-1 is paralogous to C. elegans F20D6.11 andhuman AIFM3 (AIFL).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43557
No data available
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Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            11.991M11.992M11.993M11.994M11.995M11.996M11.997M11.998M11.999M

            Sequence Details

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            Expression

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            Molecular Interactions

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              Genetic Interactions

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