Gene

zyg-9

Species
Caenorhabditis elegans
Symbol
zyg-9
Name
ZYGote defective : embryonic lethal 9
Synonyms
  • CELE_F22B5.7
  • F22B5.7
Biotype
protein coding gene
Automated Description
Predicted to enable microtubule binding activity and microtubule plus end polymerase. Involved in embryo development; meiotic spindle organization; and spindle elongation. Located in cytoplasm; kinetochore; and microtubule cytoskeleton. Orthologous to human CKAP5 (cytoskeleton associated protein 5).
WB Description
zyg-9 encodes a predicted microtubule-association protein (MAP) of the XMAP215 family; during early embryonic development, maternal zyg-9 activity is required for microtubule-dependent processes such as meiotic and mitotic spindle organization and pronuclear migration; further, zyg-9 is essential for formation of long astral microtubules; ZYG-9 is required for centrosomal localization of TAC-1, the sole C. elegans TACC family member, with which it interacts, and mutually stabilizes, in vivo; in early embryos, ZYG-9 localizes to the meiotic spindle and spindle poles, as well as to mitotic centrosomes; during metaphase and anaphase ZYG-9 localizes to the central spindle region, and during interphase ZYG-9 is cytoplasmic; proper localization of ZYG-9 to the meiotic spindle is dependent upon wild-type activity of MEI-1, an ATPase essential for meiotic spindle formation, while proper localization of ZYG-9 to centrosomes is dependent, at least in part, upon TAC-1.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12609
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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8.458M8.459M8.460M8.461M8.462M8.463M8.464M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions