Gene

jmjd-3.3

Species
Caenorhabditis elegans
Symbol
jmjd-3.3
Name
JuMonJi (transcription factor) Domain protein 3.3
Synonyms
  • C29F7.6
  • CELE_C29F7.6
Biotype
protein coding gene
Automated Description
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone H3K27me2/H3K27me3 demethylase activity. Predicted to be involved in regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex.
WB Description
C29F7.6 encodes a putative histone H3 di/trimethyllysine-27 (H3K27me2/me3) demethylase; C29F7.6 contains a C-terminal JmjC domain, and is homologous to human JMJD3, UTX (OMIM:300128), and UTY (OMIM:400009); C29F7.6 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes; however, C29F7.6 has no obvious function in mass RNAi assays.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14017
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
13.4365M13.4370M13.4375M13.4380M13.4385M13.4390M13.4395M13.4400M13.4405M13.4410M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions