Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including determination of adult lifespan; negative regulation of cGMP-mediated signaling; and response to hydrogen peroxide. Is expressed in hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A) and PDE3B (phosphodiesterase 3B).
WB Description
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including determination of adult lifespan; negative regulation of cGMP-mediated signaling; and response to alkaline pH. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Is an ortholog of human PDE3A (phosphodiesterase 3A) and PDE3B (phosphodiesterase 3B).