Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Located in cytoplasm. Is expressed in body wall musculature; hypodermal cell; intestinal cell; muscle cell; and neurons. Orthologous to human PFDN6 (prefoldin subunit 6).
WB Description
pfd-6 encodes a putative prefoldin 6 subunit, orthologous to human PFDN6 (OMIM:605660), required for normal microtubule growth and distal tip cell migration; PFD-6 is expressed cytoplasmically in most, if not all, tissues, including the germline; in mass RNAi assays, PFD-6 is required for normal mitotic spindle position, embryonic and larval viability, fertility, body shape, vulval development, and locomotion, and for normally rapid growth; pfd-6(RNAi) embryos show a reduced microtubule growth rate.