Gene

pfd-6

Species
Caenorhabditis elegans
Symbol
pfd-6
Name
PreFolDin (molecular chaperone) 6
Synonyms
  • CELE_F21C3.5
  • F21C3.5
Biotype
protein coding gene
Automated Description
Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Located in cytoplasm. Is expressed in body wall musculature; hypodermal cell; intestinal cell; muscle cell; and neurons. Orthologous to human PFDN6 (prefoldin subunit 6).
WB Description
pfd-6 encodes a putative prefoldin 6 subunit, orthologous to human PFDN6 (OMIM:605660), required for normal microtubule growth and distal tip cell migration; PFD-6 is expressed cytoplasmically in most, if not all, tissues, including the germline; in mass RNAi assays, PFD-6 is required for normal mitotic spindle position, embryonic and larval viability, fertility, body shape, vulval development, and locomotion, and for normally rapid growth; pfd-6(RNAi) embryos show a reduced microtubule growth rate.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21431
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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7.2830M7.2831M7.2832M7.2833M7.2834M7.2835M7.2836M7.2837M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions