Gene

uggt-2

Species
Caenorhabditis elegans
Symbol
uggt-2
Name
UDP-Glucose Glycoprotein glucosylTransferase 2
Synonyms
  • CELE_F26H9.8
  • F26H9.8
Biotype
protein coding gene
Automated Description
Predicted to enable UDP-glucose:glycoprotein glucosyltransferase activity and unfolded protein binding activity. Involved in IRE1-mediated unfolded protein response; regulation of embryonic development; and regulation of nematode larval development. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Orthologous to human UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1) and UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2).
WB Description
uggt-2 encodes one of two C. elegans homologs of UDP-Glc:glycoprotein glucosyltransferase (UGGT), an endoplasmic reticulum enzyme involved in quality control of glycoprotein folding; loss of uggt-2 activity via RNAi indicates that uggt-2 is an essential embryonic gene that is also required for regulating the rate of larval developmental; uggt-2 interacts genetically with ire-1 with respect to basal unfolded protein response during larval development; uggt-2 is expressed throughout larval development, with peak levels seen at the L2/L3 stages.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11226
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            9.318M9.319M9.320M9.321M9.322M9.323M9.324M9.325M9.326M9.327M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            uggt-2 molecule type
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              Genetic Interactions

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