Gene

pix-1

Species
Caenorhabditis elegans
Symbol
pix-1
Name
PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog 1
Synonyms
  • CELE_K11E4.4
  • K11E4.4
Biotype
protein coding gene
Automated Description
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in gonad morphogenesis; inductive cell migration; and neuron migration. Located in several cellular components, including adherens junction; cell periphery; and hemidesmosome. Is expressed in hermaphrodite gonad; hypodermis; and somatic gonad precursor. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to several human genes including ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6).
WB Description
pix-1 is encodes a GTPase activator protein that forms a highly conserved signaling complex with GIT-1 and PAK, and interacts with Rac/CDC42 GTPases; pix-1 is orthologous to mammalian alpha-pix (OMIM: 300267); PIX-1 work together with GIT-1 and PAK-1 independently of RAC/CDC-42 GTPases to control DTC migration during gonad morphogenesis; in epithelial morphogenesis, PIX-1, GIT-1 and PAK-1 together regulate intermediate-filament phosphorylation and CeHD biogenesis; Tension exerted by adjacent muscles or externally exerted mechanical pressure maintains GIT-1 at hemidesmosome and stimulates PAK-1 activity through PIX-1 and Rac; expressed in Z1/Z4 at L1 stage. PIX-1 is expressed in CeHDs and migrating DTCs.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46026
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            13.728M13.729M13.730M13.731M13.732M13.733M13.734M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            pix-1 molecule type
            Interactor gene
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              Genetic Interactions

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