Trna (tRNA) Splicing ENdonuclease subunit related 34
Synonyms
CELE_K08D10.12
K08D10.12
Biotype
protein coding gene
Automated Description
Predicted to enable lyase activity; nucleic acid binding activity; and tRNA-intron endonuclease activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Orthologous to human TSEN34 (tRNA splicing endonuclease subunit 34).
WB Description
K08D10.12 encodes a putative tRNA 3'-site splicing endonuclease subunit, orthologous to human TSEN34 and budding yeast SEN34; K08D10.12 is coexpressed (as is DNJ-15) with the paralogous small nuclear ribonucleoprotein (snRNP)-associated proteins RNP-2/U1A and RNP-3/U2B