Gene

pig-1

Species
Caenorhabditis elegans
Symbol
pig-1
Name
Par-1 (I)-like Gene 1
Synonyms
  • CELE_W03G1.6
  • W03G1.6
Biotype
protein coding gene
Automated Description
Enables protein serine/threonine kinase activity. Involved in several processes, including generation of neurons; hemidesmosome assembly; and regulation of apoptotic process. Located in centrosome and cytoplasm. Is expressed in several structures, including Q lineage cell; QL; QL.aa; QL.pp; and neurons. Orthologous to human MELK (maternal embryonic leucine zipper kinase).
WB Description
pig-1 encodes a serine/threonine kinase orthologous to vertebrate MELK (Maternal Embryonic Leucine zipper Kinase, OMIM:607025); in C. elegans, PIG-1 activity is required for asymmetric neuroblast divisions, including that of the QL/R.p and HSN/PHB neuroblast lineages, that result in one neuronal precursor and one apoptotic cell; in regulating asymmetric division of QL/R.p, pig-1 functions cell autonomously in a pathway with par-4, strd-1, and mop-25.2 which encode orthologs of the LKB1 kinase, STRAD pseudokinase, and MO25 adaptor protein, respectively; pig-1 is ubiquitously expressed in early embryos, broadly expressed in dividing larval cells, and silent in adults; PIG-1 localizes to the cytoplasm and to centrosomes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24343
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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508k510k512k514k516k518k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions