Gene

zfh-2

Species
Caenorhabditis elegans
Symbol
zfh-2
Name
Zinc Finger and Homeobox 2
Synonyms
  • CELE_ZC123.3
  • let-129
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in body wall musculature; enteric muscle; nerve ring; neurons; and vulval muscle. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including Marsili syndrome; familial atrial fibrillation; hepatocellular carcinoma; lung non-small cell carcinoma (multiple); and spinocerebellar ataxia type 4. Orthologous to several human genes including ZFHX3 (zinc finger homeobox 3) and ZFHX4 (zinc finger homeobox 4).
WB Description
zfh-2 is a homeobox gene of the ZF (zinc finger class); it encodes three homeodomains and encodes at last 15 zinc fingers; the ZF class is subdivided into several families; zfh-2 belongs to the Zfhx family and is orthologous to Drosophila zfh-2, and the three paralogous human genes ZFHX2, ZFHX3, and ZFHX4 (zinc finger homeobox 2, 3, 4); zfh-2 is involved in hermaphrodite genitalia development, locomotion, nematode larval development and receptor-mediated endocytosis; zfh-2 is predicted to have DNA binding activity and zinc ion binding activity, based on protein domain information; zfh-2 is expressed in the anal depressor muscle, anal sphincter muscle, body wall musculature, vulval muscle, and the nerve ring.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45891
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            805k810k815k820k825k830k

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            zfh-2 molecule type
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              Genetic Interactions

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