Version: 8.0.0
Date: Tue Jan 28 2025
dvl3a
Danio rerioZFIN:ZDB-GENE-010319-1
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

dvl3a

Species
Danio rerio
Symbol
dvl3a
Name
dishevelled segment polarity protein 3a
Synonyms
  • dvl3
  • wu:fb75f04
Biotype
protein coding gene
Automated Description
Predicted to enable frizzled binding activity. Involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway. Acts upstream of or within canonical Wnt signaling pathway; convergent extension involved in axis elongation; and post-anal tail morphogenesis. Located in cell cortex and spindle. Is expressed in liver and male organism. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3 and lung cancer. Orthologous to human DVL3 (dishevelled segment polarity protein 3).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10878
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCz11
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          dvl3a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            dvl3a role
            dvl3a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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