Gene

jag1a

Species
Danio rerio
Symbol
jag1a
Name
jagged canonical Notch ligand 1a
Synonyms
  • cb243
  • jag1
Biotype
protein coding gene
Automated Description
Predicted to enable Notch binding activity. Involved in positive regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including hematopoietic stem cell differentiation; regulation of non-canonical NF-kappaB signal transduction; and thyroid gland development. Is active in plasma membrane. Is expressed in several structures, including digestive system; lens placode; nervous system; neural keel; and neural tube. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44097
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
51.105M51.110M51.115M51.120M51.125M51.130M51.135M51.140M51.145M51.150M51.155M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions