Predicted to enable Notch binding activity. Involved in positive regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including hematopoietic stem cell differentiation; regulation of non-canonical NF-kappaB signal transduction; and thyroid gland development. Is active in plasma membrane. Is expressed in several structures, including digestive system; lens placode; nervous system; neural keel; and neural tube. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1).