Gene

pola1

Species
Danio rerio
Symbol
pola1
Name
polymerase (DNA directed), alpha 1
Synonyms
  • cb678
  • pola
Biotype
protein coding gene
Automated Description
Predicted to enable DNA binding activity; DNA-directed DNA polymerase activity; and chromatin binding activity. Predicted to be involved in lagging strand elongation; leading strand elongation; and mitotic DNA replication initiation. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Is expressed in immature eye; nervous system; neural tube; pectoral fin musculature; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10322
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
23.85M23.86M23.87M23.88M23.89M23.90M23.91M23.92M23.93M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions