Version: 8.0.0
Date: Tue Jan 28 2025
gclm
Danio rerioZFIN:ZDB-GENE-030131-5906
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

gclm

Species
Danio rerio
Symbol
gclm
Name
glutamate-cysteine ligase, modifier subunit
Synonyms
  • GLCLR
  • id:ibd3182
Biotype
protein coding gene
Automated Description
Predicted to enable glutamate-cysteine ligase catalytic subunit binding activity and glutamate-cysteine ligase regulator activity. Acts upstream of or within cell redox homeostasis. Predicted to be part of glutamate-cysteine ligase complex. Is expressed in several structures, including brain; germ ring; immature eye; liver; and pronephric duct. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13295
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCz11
            Viewer Help
            15.270M15.271M15.272M15.273M15.274M15.275M15.276M15.277M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            gclm molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              gclm role
              gclm genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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