Gene

hspb1

Species
Danio rerio
Symbol
hspb1
Name
heat shock protein, alpha-crystallin-related, 1
Synonyms
  • cb153
  • cb660
Biotype
protein coding gene
Automated Description
Predicted to enable unfolded protein binding activity. Acts upstream of or within regulation of myofibril size; response to arsenic-containing substance; and response to heat. Located in cytoplasm and nucleus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; autosomal dominant distal hereditary motor neuronopathy 3; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11527
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCz11
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            3.570M3.572M3.574M3.576M3.578M3.580M3.582M3.584M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            hspb1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              hspb1 role
              hspb1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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