Version: 8.0.0Date: Tue Jan 28 2025
Gene
arhgef2a
- Species
- Danio rerio
- Symbol
- arhgef2a
- Name
- Rho guanine nucleotide exchange factor (GEF) 2a
- Synonyms
- arhgef1
- arhgef1a
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including actin filament organization; positive regulation of neuron differentiation; and regulation of Rho protein signal transduction. Predicted to act upstream of or within several processes, including cell division; innate immune response; and nervous system development. Predicted to be located in several cellular components, including Golgi apparatus; bicellular tight junction; and spindle. Predicted to be active in cytoskeleton and ruffle membrane. Is expressed in several structures, including blood vessel; hindbrain neural plate; immature eye; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in immunodeficiency 62 and neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to several human genes including ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2).
- ZFIN Description
- Not Available
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR12673
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr19:11039517...11106315 (66.80 kb)
- Chr19:11129318...11157659 (28.34 kb)
- Assembly version
- GRCz11
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.