Version: 8.0.0
Date: Tue Jan 28 2025
tph1b
Danio rerioZFIN:ZDB-GENE-030805-6
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

tph1b

Species
Danio rerio
Symbol
tph1b
Name
tryptophan hydroxylase 1b
Synonyms
  • tph1-2
  • tph1l
Biotype
protein coding gene
Automated Description
Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation and response to hypoxia. Predicted to be active in neuron projection. Is expressed in axial mesoderm; axis; epiphysis; margin; and raphe nucleus. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and nicotine dependence. Orthologous to human TPH1 (tryptophan hydroxylase 1).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11473
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Must provide at least one subject
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
        la2Tg + MO1-tph1a + MO1-tph1b + MO2-tph2
        has condition:
        standard conditions
        • hematopoietic multipotent progenitor cell decreased amount, abnormal
        		ZFIN
        pd27Tg; zf169Tg + MO1-tph1a + MO1-tph1b + MO2-tph2
        has condition:
        standard conditions
        • hematopoietic multipotent progenitor cell decreased amount, abnormal
        		ZFIN
        tph1aot203/ot203 + MO2-tph1b
        has condition:
        standard conditions
        • integument neuroepithelial cell ab1-serotonin labeling decreased distribution, abnormal
        		ZFIN
        tph1aot203/ot203; tph1bf234jy/f234jy
        has condition:
        standard conditions
        • integument neuroepithelial cell ab1-serotonin labeling decreased distribution, abnormal
        • trunk serotonin decreased amount, abnormal
        		ZFIN
        tph1aot203/ot203; tph1bf234jy/f234jy
        has condition:
        hypoxia
        • response to hypoxia process quality, abnormal
        		ZFIN
        tph1aot204/ot204 + MO2-tph1b
        has condition:
        standard conditions
        • integument neuroepithelial cell ab1-serotonin labeling decreased distribution, abnormal
        		ZFIN
        tph1aot204/ot204; tph1bf234jy/f234jy
        has condition:
        standard conditions
        • integument neuroepithelial cell ab1-serotonin labeling decreased distribution, abnormal
        • trunk serotonin decreased amount, abnormal
        		ZFIN
        tph1aot204/ot204; tph1bf234jy/f234jy
        has condition:
        hypoxia
        • response to hypoxia process quality, abnormal
        		ZFIN
        tph1bf234jy/f234jy
        has condition:
        standard conditions
        • calcium ion transmembrane transport decreased occurrence, abnormal
        • integument neuroepithelial cell ab1-serotonin labeling decreased distribution, abnormal
        		ZFIN
        tph1bf234jy/f234jy
        has condition:
        hypoxia
        • response to hypoxia process quality, abnormal
        		ZFIN
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        Sequence Feature Viewer

        Genome location
        Assembly version
        GRCz11
        Viewer Help
        Data currently unavailable; sequence viewer under construction

        Sequence Details

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        Expression

        Primary Sources
        Other Sources
        Must provide at least one subject
        Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

        Molecular Interactions

        tph1b molecule type
        Interactor gene
        Interactor species
        Interactor molecule type
        Detection methods
        Source
        Reference
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          Genetic Interactions

          tph1b role
          tph1b genetic perturbation
          Interactor gene
          Interactor species
          Interactor role
          Interactor genetic perturbation
          Interaction type
          Phenotype or trait
          Source
          Reference
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