Gene

fhit

Species
Danio rerio
Symbol
fhit
Name
fragile histidine triad diadenosine triphosphatase
Synonyms
  • zgc:73176
Biotype
protein coding gene
Automated Description
Predicted to enable bis(5'-adenosyl)-triphosphatase activity and ubiquitin protein ligase binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and nucleotide metabolic process. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23089
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
54.0788M54.0790M54.0792M54.0794M54.0796M54.0798M54.0800M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions