Gene

mre11a

Species
Danio rerio
Symbol
mre11a
Name
MRE11 homolog A, double strand break repair nuclease
Synonyms
  • fc38f05
  • wu:faa63d12
Biotype
protein coding gene
Automated Description
Predicted to enable single-stranded DNA endodeoxyribonuclease activity. Acts upstream of or within hematopoietic stem cell homeostasis and regulation of telomere maintenance. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of Mre11 complex. Predicted to be active in site of double-strand break. Is expressed in alar plate midbrain region; digestive system; eye; immature eye; and midbrain. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10139

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

No data available

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions