MRE11 homolog A, double strand break repair nuclease
Synonyms
fc38f05
wu:faa63d12
Biotype
protein coding gene
Automated Description
Predicted to enable single-stranded DNA endodeoxyribonuclease activity. Acts upstream of or within hematopoietic stem cell homeostasis and regulation of telomere maintenance. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of Mre11 complex. Predicted to be active in site of double-strand break. Is expressed in alar plate midbrain region; digestive system; eye; immature eye; and midbrain. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease).