Version: 8.0.0
Date: Tue Jan 28 2025
tpm1
Danio rerioZFIN:ZDB-GENE-040426-854
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

tpm1

Species
Danio rerio
Symbol
tpm1
Name
tropomyosin 1 (alpha)
Synonyms
  • TPM1-1
  • zgc:171719
Biotype
protein coding gene
Automated Description
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cardiac muscle contraction. Predicted to be active in actin filament. Is expressed in adaxial cell; heart; and musculature system. Human ortholog(s) of this gene implicated in congenital myopathy 4A; dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy 3; and nemaline myopathy 1. Orthologous to several human genes including TPM1 (tropomyosin 1).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19269

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          No data available

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          tpm1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            tpm1 role
            tpm1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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