irf8

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Species

Danio rerio

Symbol

irf8

Name

interferon regulatory factor 8

Synonyms

• zgc:92252

Biotype

protein coding gene

Automated Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within microglia development; regulation of macrophage differentiation; and regulation of neutrophil differentiation. Predicted to be active in nucleus. Is expressed in several structures, including endothelial cell; eye; hematopoietic cell; hematopoietic system; and yolk. Human ortholog(s) of this gene implicated in Behcet's disease; immunodeficiency 32A; immunodeficiency 32B; multiple myeloma; and systemic lupus erythematosus. Orthologous to human IRF8 (interferon regulatory factor 8).

ZFIN Description

Not Available

Cross References

• ENSEMBL:ENSDARG00000056407
• NCBI_Gene:436895

Show All 3

Additional Information

Literature

Orthology

Gene tree

PANTHER:PTHR11949

Paralogy

Function - GO Annotations

Pathways

No data available

No data available

No data available

Read more about the GO-CAM Data Model.

Phenotypes

Primary Sources

• ZFIN

Other Sources

None

Disease Associations

Alleles and Variants

Transgenic Alleles

Models

Sequence Feature Viewer

Sequence Details

Expression

Primary Sources

• ZFIN (all)
• ZFIN (wild type)
• ZFIN (images)

Other Sources

• Single Cell Expression Atlas
• Expression Atlas

Molecular Interactions

Genetic Interactions